Spiroton (Spironolactone) is an effective potassium-sparing diuretic. The medical use of this drug consists in the treatment of a number of diseases associated with the insufficient functioning of the kidneys and liver, for lowering the pressure in the circulatory system, for edema of different degrees, for heart failure.
Spironolactone is an antagonist of the receptor of the hormone Aldosterone. This hormone (Aldosterone) is produced by the adrenal cortex and it is the main mineralocorticosteroid hormone of the adrenal cortex in humans. In some animal species, the main natural mineralocorticoid is deoxycorticosterone, not aldosterone, but for humans, deoxycorticosterone is relatively inactive.
Mineralocorticoids cause an increase in tubular reabsorption of sodium cations, chlorine anions and at the same time enhance tubular excretion of potassium cations and increase the ability of tissues to retain water, which contributes to the transfer of fluid and sodium from the vascular bed to the tissues.
Since Spiroton blocks the Aldosterone receptors, all biological effects of Aldosterone decrease. Increased diuresis causes a hypotensive effect, which is variable. The maximum effect is observed 7 hours after taking the capsules inside and lasts at least 24 hours. Diuretic effect is manifested on 2-5 days
In medicine Spiroton (Spironolactone) is used for treatment in patients with congestive heart failure , essential hypertension, mainly in the case of hypokalemia (usually in combination with other antihypertensive drugs), cirrhosis of the liver, accompanied by edema and / or ascites, primary hyperaldosteronism, edema due to nephrotic syndrome, hypokalemia, in case of impossibility of using another therapy.
Spirotone is also widely used in sports, especially in bodybuilding. The using of this product solves several complex problems.
Fast weight loss is a fairly common task for athletes who have an urgent need to maintain a weight category. Using of Spironolactone for several days helps to significantly reduce body weight.
In bodybuilding diuretics are extremely important drugs that are included in the first-aid kit of professionals. This is explained by the fact that during the preparation for performances, an important factor is not only getting rid of the fat layer, but also from excess moisture, which can hide the muscles relief.
Applying as an anti-androgen agent, such as lowering the amount of male sex hormones (androgens), is extremely useful for female athletes who use Androgenic Anabolic Steroids (AAS) during the preparation period. Spiroton application allows them to get rid of the manifestation of virilization.
Applying
Using this medicine for therapeutic purposes, you should consult with the doctor about the dosage and period of applying.
In sports this tool is used in a higher dosage, as a quick effect is needed, and the average body weight is an order of magnitude higher than the common, this should also be taken into account.
The drug begins to actively show its effect on the second-third day of applying; it should be noticed not to increase the dosage.
In bodybuilding this drug is recommended for use during the 10-14 days in small dosages for the smooth result. In the last two days before the performance, a bolt dosage is usually taken to remove the maximum possible amount of water.
This applying of this drug should be done only under the supervision of medical workers in order to avoid dangerous attacks of dehydration in time.
The dosage is made taking into account of the state of health and body weight of the athlete. On average, it is 50-100 mg per day for 10-14 days, but it can be increased significantly.
Before applying this drug, you should consult with your doctor if you have problems with: Kidneys, Liver, and Heart. Also if you are using any other drugs you should ask the doctor about their combination with Spiroton.
Contraindications
Hypersensitivity to the active substance or other components of the drug.
Severe impairment of nitrogen excretory function of the kidneys (glomerular filtration rate <10 ml / min), anuria.
Hyperkalemia, hyponatremia.
Addison's disease.
Simultaneous use with potassium-sparing diuretics and potassium preparations due to the possibility of developing of hyperkalemia.
Hyperkalemia may develop in patients with impaired renal function or in patients with excessive potassium intake. This can cause the development of fatal arrhythmias. In case of hyperkalemia, spironolactone should be discontinued and active measures should be taken to reduce serum potassium to normal levels.
Side effects
This drug has a fairly large number of side effects, but they are almost never manifest in healthy users. But in cases of violations of recommendations of using or in the case of an individual allergic reaction, you may feel the following symptoms and:
Vomiting;
Dry mouth (associated with dehydration);
Violation of movement coordination;
Problems with orientation in space;
Dizziness;
Problems with potency;
In rare cases, symptoms of gynecomastia.
Also Spirotone can cause allergic reactions such as drug fever, urticaria, maculopapular and erythematous rash, Stevens-Johnson syndrome, toxic epidermal necrolysis.
Spirotone administration can lead to changes in biochemical markers and it can cause hypercreatininemia, hyperuricemia, impaired water-electrolyte metabolism and/or acid-base state (metabolic hypochloremic acidosis or alkalosis).
Other side effects of Spirotone include agranulocytosis, thrombocytopenia, megaloblastosis, and spasms of the calf muscles, muscle spasm, alopecia, and itchy skin.
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Warning!
This drug is a medical product and requires following recommendations of its usage and storage. It should be stored in the cool dark place, avoiding direct sunlight. It’s also necessary to keep this drug out of children`s reach!
You MUST consult with your attending physician before you start using this drug. We also ask you to take into account that this drug may cause some side effects. Some of them can be life-threatening. If you notice any disturbing symptoms you should to contact with your physician. In some cases, it is necessary to stop taking the drug for a while. Also, you must inform your doctor if you taking Spironolactonewith other medicines. So physician can prescribe proper treatment and help you to avoid any unpleasant adverse effects.
